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Is liver biopsy still necessary? – M2BPGi as a non-invasive marker of fibrosis

Liver fibrosis silently and insidiously progresses toward cirrhosis and cancer – is biopsy the only reliable way to detect it in time? M2BPGi, a glycoprotein biomarker that reflects the activity of the fibrogenic cells themselves, offers something that existing indices like FIB-4 and APRI cannot: insight into the living fibrogenic process, not just its remnants. Can a single serum marker replace the needle and the risks that come with it?

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Lp(a): An important cardiovascular risk factor on the threshold of new therapies?

Did you know that nearly one in five people carries a genetically determined increased risk of heart attack, without even being aware of it? Lipoprotein(a) is a molecule that has stood in cholesterol’s shadow for decades, yet today it is recognized as an important cardiovascular risk factor that lifestyle changes and statins cannot significantly influence. What does its value mean for us, and does the new generation of drugs offer a solution?

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Early puberty – a natural trend or a public health issue?

Puberty is a complex developmental biological process during which the reproductive system matures and secondary sexual characteristics develop, normally beginning between the ages of 8 and 13 in girls and between 9 and 14 in boys. However, in recent times a trend of earlier onset of puberty has been observed. The question arises whether early maturation represents a natural trend or a serious public health problem with long-term consequences.

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Dietary supplements for menstrual problems and menopause: why don’t they help everyone?

Soy and red clover are rich sources of genistein and daidzein, isoflavones that are used as dietary supplements to alleviate menstrual disorders, menopausal symptoms, osteoporosis, and polycystic ovary syndrome. Soy and red clover derived phytoestrogens are well known for their hormonal effects; however, it is becoming increasingly evident that their effects are not the same in all individuals.

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